Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 215, Issue 1-2, Pages 36-42Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2009.07.016
Keywords
Chemokine; LTP; Hippocampus; Glutamate receptor; fEPSP; Adenosine receptor
Categories
Funding
- Ministero Universita & Ricerca scientifica
- Fondazione Cenci Bolognetti
- Ministero Salute (Ricerca finalizzata)
- Swedish Science Research Council
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We have examined how the chemokine fractalkine/CX(3)CL1 influences long-term potentiation (LTP) in CA1 mouse hippocampal slices. Field potentials (fEPSPs) were recorded upon electrical stimulation of Schaffer collaterals. It was found that application of CX(3)CL1 inhibits LTP when present during the critical induction period. LTP impairment (i) failed to occur in CX(3)CR1 deficient mice (CX3CR1GFP/GFP) and in the presence of okadaic acid (OA); (ii) required the activation of adenosine receptor 3 (A(3)R), since it was prevented in A(3)R-deficient mice or by MRS1523, a selective A(3)R antagonist. Together, these findings indicate that CX(3)CL1 inhibits hippocampal LTP through A(3)R activity. (C) 2009 Elsevier B.V. All rights reserved.
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