Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 207, Issue 1-2, Pages 45-56Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2008.11.009
Keywords
Systemic Lupus Erythematosus; Neuropsychiatric lupus; Anti-DNA antibodies; Depression
Categories
Funding
- NIAMS NIH HHS [R56 AR048692, R56 AR048692-06A1] Funding Source: Medline
Ask authors/readers for more resources
Many lupus patients develop neuropsychiatric manifestations, including cognitive dysfunction, depression, and anxiety. However, it is not clear if neuropsychiatric lupus is a primary disease manifestation, or is secondary to non-CNS disease. We found that MRL/lpr lupus-prone mice exhibited significant depression-like behavior already at 8 weeks of age, despite normal visual working memory, locomotor coordination and social preference. Moreover, depression was significantly correlated with titers of autoantibodies against DNA, NMDA receptors and cardiolipin. Our results indicate that lupus mice develop depression and CNS dysfunction very early in the course of disease, in the absence of substantial pathology involving other target organs. (C) 2008 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available