Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 211, Issue 1-2, Pages 39-48Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2009.03.011
Keywords
Autism; Immune disorder; Neurobehavioral problems; Pregnant dam model; Transplacental antibodies
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Funding
- Hussman Foundation
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A pregnant mouse model was used to compare the effect of IgG, administered E13-E18, from mothers of children with autistic disorder (MCAD), to controls (simple- and IgG-) on behavioral testing in offspring. Mice, exposed in-utero to MCAD-IgG, as adolescents, were more active during the first ten minutes of central field novelty testing and, as adults, displayed anxiety-like behavior on a component of the elevated plus maze and had a greater magnitude of startle following acoustic stimulation. On a social interaction paradigm, adult mice had alterations of sociability. Pilot studies of immune markers in MCAD IgG-exposed embryonic brains suggest evidence of cytokine and glial activation. These studies demonstrate that the transplacental passage of IgG from MCAD is capable of inducing long-term behavioral consequences. (C) 2009 Elsevier B.V. All rights reserved.
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