Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 216, Issue 1-2, Pages 98-102Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2009.09.006
Keywords
Multiple sclerosis; Calprotectin; Cerebrospinal fluid; Biomarkers
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Calprotectin is produced by activated monocytes and microglia, and cerebrospinal fluid (CSF) levels could be a marker of neuroinflammation. Calprotectin was detectable in CSF from 13.8% of normal controls, compared to 90.5% of patients with neurological infections (p<0.001). In CSF from patients with multiple sclerosis (MS) and clinically isolated demyelinating syndrome, calprotectin was detected in 64.7% within 2 weeks after symptom debut compared to 30.8% between 2 and 4 weeks and 17.0% thereafter (p<0.001). We conclude that CSF calprotectin reflects the disease activity in MS but does not discriminate between MS and other inflammatory or infectious conditions. (C) 2009 Elsevier B.V. All rights reserved.
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