Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 215, Issue 1-2, Pages 102-107Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2009.08.004
Keywords
Multiple sclerosis; Epstein-Barr virus; EBNA-1; Autoimmune diseases; HLA; Case control studies
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Funding
- Swedish Association of Neurologically Disabled
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Epitope reactivity of multiple sclerosis (MS) plasma antibodies against the Epstein-Barr virus protein EBNA-1 and its association with HLA DRB1*1501 status was investigated in a case-referent study. Based on EBNA-1 fragment reactivity and the effect of peptide blocking, four 29-36 amino acid long EBNA-1 fragments were selected for detailed studies. MS cases had increased antibody reactivity against several EBNA-1 domains, of which antibodies against EBNA-1 (amino acid 385-420) in HLA DRB1*1501 positive individuals were associated with a 24-fold risk increase for MS. The data need confirmation in a larger sample but suggest a role for this epitope in the autoimmune pathogenesis of MS. (C) 2009 Elsevier B.V. All rights reserved.
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