Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 213, Issue 1-2, Pages 135-141Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2009.05.012
Keywords
Vitamin D; Multiple sclerosis; Regulatory T cells; Naive T helper cells; Memory T helper cells
Categories
Funding
- The National Multiple Sclerosis Society [PP1202]
- Multiple Sclerosis Center of Excellence-East
- EMD-Serono
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Vitamin D has been associated with a decreased risk of multiple sclerosis (MS). In this study, serum 1, 25-dihydroxyvitamin D (1, 25-(OH)2 vitD) and 25-hydroxyvitamin D (25-OH vitD), regulatory T cell percentages and naive and memory T helper cell subsets were measured in 26 patients with multiple sclerosis, 21 who were not on treatment with disease modifying therapy. These studies showed an inverse correlation between 25-OH vitD levels and Treg cell percentages and a direct correlation between Treg cell percentages and 1, 25-(OH)2 vitD:25-OH vitD ratios. In addition, 25-OH vitD levels correlated directly and 1, 25-(OH)2 vitD:25-OH vitD ratios correlated inversely with CXCR3+ naive T helper cell percentages and CXCR3+naive:CXCR3+ memory T helper cell ratios. All together, these data demonstrate that vitamin D measurements can reflect measures of immune status among patients with MS. Published by Elsevier B.V.
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