Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 212, Issue 1-2, Pages 3-9Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2009.05.003
Keywords
Systemic Lupus Erythematosus; Neuropsychiatric manifestations; Autoantibodies; Pathogenesis; Neurons; Endothelium
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In the course of Systemic Lupus Erythematosus (SLE), a variety of neuropsychiatric disturbances is reported with a prevalence ranging from 17% to 75%. The diagnosis of these syndromes is difficult and requires a careful psychiatric evaluation. Distinct autoantibodies detectable in serum or cerebrospinal fluid of patients with SLE are associated with the presence of neuropsychiatric disorders. These autoantibodies may have a pathogenic relevance in neuropsychiatric SLE or they may be merely an epiphenomenon. This review describes the various autoantibodies reported to be associated with neuro psychiatric manifestations in SLE and discusses their possible role. (C) 2009 Elsevier B.V. All rights reserved.
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