Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 217, Issue 1-2, Pages 51-54Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2009.09.020
Keywords
Neutrophil; Prolyl endopeptidase; PGP; Collagen; Inflammation
Categories
Funding
- Wellcome Trust [082727/Z/07/Z]
- NIH [RR19231, P30CA13148, P50AT00477, U54CA100949, P30AR050948, P30DK740380]
- National Heart Lung and Blood Institute (NHLBI) [R01 HL07783, R01 HL090999, R01 HL087824]
- Wellcome Trust [082727/Z/07/Z] Funding Source: Wellcome Trust
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Prolyl endopeptidase (PE), a protease that cleaves after proline residues in oligopeptides, is highly active in brain and degrades neuropeptides in vitro. We have recently demonstrated that PE, in concert with MMP's, can generate PGP (proline-glycine-proline), a novel, neutrophil chemoattractant, from collagen. In this study, we demonstrate that human peripheral blood neutrophils contain PE, which is constitutively active, and can generate PGP de novo from collagen after activation with LPS. This novel, pro-inflammatory role for PE raises the possibility of a self-sustaining pathway of neutrophilic inflammation and may provide biomarkers and therapeutic targets for diseases caused by chronic, neutrophilic inflammation. (C) 2009 Elsevier B.V. All rights reserved.
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