Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 213, Issue 1-2, Pages 84-90Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2009.05.015
Keywords
Multiple sclerosis; Experimental allergic encephalomyelitis; Inflammation; ICAM-1; Magnetic resonance imaging
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Animal models of experimental allergic encephalomyelitis (EAE) are the most commonly used animal models for studying the pathogenesis of human multiple sclerosis (MS) as well as for target validation and compound characterization in pharmacology. By using an EAE model in Lewis rats, we focus on its neuroimmunological characterization with special attention to disease-involved cytokines, chemokines, and adhesion molecules. Furthermore, we used MR imaging to investigate macrophage infiltration and ICAM-1 expression in lesional spinal cord. Overall, due to its inflammatory character, this model is suggested to be used in early drug discovery particularly directed against acute inflammatory processes. (C) 2009 Elsevier B.V. All rights reserved.
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