Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 213, Issue 1-2, Pages 131-134Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2009.05.013
Keywords
MS; Autoimmunity; NADPH oxidase; Reactive oxygen species; Phagocytes
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Funding
- Research Foundation of the Gothenburg Multiple Sclerosis Society
- Swedish Medical Research Council
- Swedish Association
- Inga-Britt and Arne Lundberg Research Foundation
- Torsten and Ragnar Soderberg Foundation
- Anna-Lisa and Bror Bjornsson Foundation, Gothenburg, Sweden
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This study investigated the relationship between the formation of NADPH oxidase-dependent oxygen radicals in peripheral blood leukocytes ('respiratory burst') and disease severity in patients with multiple sclerosis (MS). Oxygen radical production was induced by formyl-Met-Leu-Phe (fMLF) Trp-Lys-Tyr-Met-Val-Met-NH2 (WKYMVM) or phorbol myristate acetate (PMA) and was assessed by quantifying superoxide anion, i.e. the initial radical formed by the NADPH oxidase. Disease severity was evaluated using the Multiple Sclerosis Severity Score (MSSS). In patients with severe disease, the production of superoxide anion was significantly lower for all three inducers of radical formation (p = 0.04-0.004). Our findings are supportive of a protective role of oxygen radicals in autoimmunity. (C) 2009 Elsevier B.V. All rights reserved.
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