Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 210, Issue 1-2, Pages 128-130Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2009.03.005
Keywords
Age of onset; HLA-DRB1*15 antigen; Multiple sclerosis; Oligoclonal bands; Prognosis; Survival analysis
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Funding
- Bibbi and Nils Jensen Foundation
- Karolinska Institute
- Swedish Association of Neurologically Disabled
- Swedish Brain Foundation
- Swedish Research Council
- European Union [LSHM-CF-2005-018637]
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Carriage of HLA-DRB1*15 is the most important genetic risk factor in multiple sclerosis (MS), while CSF-specific oligoclonal immunoglobulin G bands (CCB) constitute the most sensitive biochemical marker for diagnosing MS. We demonstrated in an earlier study the interdependence of HLA-DRB1 genotype and CCB status; the effect of these phenotypic features on MS prognosis remains controversial, however. We investigated by survival analysis the impact of each variable on age at two important MS milestones: onset of clinical symptoms and an Expanded Disability Status Scale (EDSS) score of 6.0. Both carriage of HLA-DRB1*15 and the presence of OCB hastened attainment of EDSS 6.0. (C) 2009 Elsevier B.V. All rights reserved.
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