Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 209, Issue 1-2, Pages 40-49Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2009.01.020
Keywords
Ginseng saponin; Microglia; Cytokine; iNOS; Signaling pathway
Categories
Funding
- Korea Ginseng Cooperation
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In the present study, we investigated the effect of ginseng extract (KRG) and total saponins (GTS) on microglial activation. KRG and GTS inhibited LPS-induced expression of iNOS, MMP-9 and proinflammatory cytokines in microglial cells. Suppression of microglial activation by ginseng was also observed in the mouse brain inflamed by LPS. Furthermore, KRG and GTS significantly suppressed NF-kappa B and MAP kinase activities, which are upstream signaling molecules in inflammation. Among the individual ginsenosides tested, Rh2, Rh3 and compound K significantly inhibited LPS-induced iNOS and cytokine expressions. Therefore, the inhibition of microglial activation by ginseng saponins may a good potential therapeutic modality for neurodegenerative diseases. (C) 2009 Elsevier B.V. All rights reserved.
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