Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 199, Issue 1-2, Pages 83-93Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2008.05.013
Keywords
EAE; multiple sclerosis; T cells; microglia; axons
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Funding
- National Multiple Sclerosis Society (USA) [CA 1029-A-2, TR 3760-A-3]
- Nancy Davis Center without walls
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We measured inflammatory and neural markers of disease from 7 days to one year after induction of experimental autoimmune encephalomyelitis (EAE) by immunization with myelin oligodendrocyte glycoprotein (MOG) peptide. Axon loss began before behavioral signs when T cell infiltration and microglial activation were very subtle. Remyelination was only detectable ultrastructurally. Axon numbers in the dorsal column plateau around day 30 p.i. while behavioral measures (EAE scores, rotarod, grip strength) partially recover. These results provide a starting point for testing potential neuroprotective treatments I or multiple sclerosis (MS). (C) 2008 Elsevier B.V. All rights reserved.
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