Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 198, Issue 1-2, Pages 62-68Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2008.04.022
Keywords
neurotransmission; chemokines; brain localization; dopamine; acetylcholine; vasopressin; GABA; calcium
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Funding
- l'Agence Nationale pour la Recherche (ANR) [R06282DS]
- University Pierre and Marie Curie (Paris VI)
- Institut National de la Sante et de la Recherche Medicale (INSERM), France
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Chemokines are not only mediators of the immune system and expressed in inflammatory situations. They are also Constitutively expressed in the brain in both glial cells and neurons. Several recent evidence suo est that they can have a neurotransmitter/neuromodulatory role on brain functions similar to several neuropeptides reported so far. The aim of this short review is to illustrate that point using two chemokine systems, SDF-1/CXCL12 and its receptor CXCR4 and MCP-1/CCL2 and its receptor CCR2. (C) 2008 Elsevier B.V. All rights reserved.
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