Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 198, Issue 1-2, Pages 92-97Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2008.04.024
Keywords
astroglia; glial precursor cells; chemokines; metalloproteinases; shedding; chemotaxis; proliferation; neuroinflammation; glioma
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Funding
- Deutsche Forschungsgemeinschaft [LU 869/3-1]
- IZKF Biomat of the RWTH Aachen
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The transmembrane chemokines CX3CL1 and CXCL16 mediate chemotaxis and cell to cell adhesion by interaction with their receptors CXCR6 and CX3CR1, respectively. We here summarize reports oil the expression, regulation and proteolytic processing of transmembrane chemokines by glial cells, their activity on glial cells/glial precursor cells and their role in glial cell cross-talk under physiological and pathophysiological conditions. (C) 2008 Elsevier B.V. All rights reserved.
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