Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 203, Issue 1, Pages 3-11Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2008.06.007
Keywords
gamma delta T cell; Antigen presentation; MHC class II; Interleukin-17
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Funding
- NEI NIH HHS [R01 EY017373, EY014366, R01 EY014366-06, R01 EY017373-02, R24 EY015636, EY017373, R01 EY014366] Funding Source: Medline
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Although human and bovine gamma delta T cells were shown to express MHC class II antigen and function as APCs, attempts to determine if mouse gamma delta T cells have similar functions remained unsuccessful. We now show that gamma delta T cells derived from immunized mice also can be induced to express MHC class II and co-stimulatory molecules after activation in vitro, and are capable of antigen presentation. Using highly purified gamma delta T cells, we found that, unlike human gamma delta T cells, the expression of MHC class II molecules by mouse gamma delta T cells is limited to newly activated cells. Highest levels of MHC class II expression were seen on activated gamma delta T cells that had lost most surface-expressed gamma delta TCR while exhibiting increased levels of intracellular gamma delta TCR. In the absence of further stimulation, MHC class II expression gradually declined with the gamma delta T cells regaining their surface TCR. We also show that cytokine-activated gamma delta T cells can also express MHC class II antigen and exercise antigen-presenting activity. (C) 2008 Published by Elsevier B.V.
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