Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 200, Issue 1-2, Pages 27-40Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2008.05.019
Keywords
EAE; Myelin; Mast cells; Multiple sclerosis
Categories
Funding
- European Community's Sixth Framework Programme [504926]
- Foundation Foreman Casah Trieste, Italy
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A role tor mast cells (MC) in the pathogenesis of multiple sclerosis (MS) has been suggested, based on the analysis of human lesions and on an animal model of the disease (EAE). What role MC play in the development of MS is not well understood. We hypothesized that the link connecting MC with demyelinating diseases may be represented by their interaction with myelin. Here we show that myelin can activate mast cells. This process could be a key event in the mast cell function required for inducing EAE in mice and possibly in MS in man. (c) 2008 Elsevier B.V. All rights reserved.
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