Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 198, Issue 1-2, Pages 113-120Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2008.04.011
Keywords
neuropathic pain; spinal cord; microglia; astrocytes; interleukin-10; gene therapy
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Funding
- NIDA NIH HHS [R01 DA018156, R01 DA018156-05] Funding Source: Medline
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Microglia and/or astrocytes play a significant role in the creation and maintenance of exaggerated pain states with inflammatory and/or neuropathic etiologies. The chemokine, fractalkine, has several functions, including the newly recognized role of mediating neuropathic pain conditions. Although constitutively expressed and released during inflammation, increased release of fractalkine binds to and activates microglia leading to pathological pain. We review the critical role of fractalkine in neuron-to-glial communication after peripheral nerve injury and inflammation and explore anti-inflammatory cytokines like interleukin-10 as a novel and effective approach for clinical pain control. (C) 2008 Elsevier B.V. All rights reserved.
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