Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 199, Issue 1-2, Pages 24-34Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2008.04.034
Keywords
cytokines; metalloproteinases; experimental autoimmune encephalomyelitis; neuroinflammation; proteases
Categories
Funding
- Canadian Institutes of Health Research
- Alberta Heritage Foundation for Medical Research
- Multiple Sclerosis Society of Canada
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Several matrix metalloproteinase (MMP) members contribute to pathology in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). As the role of MMP-12 in EAE has been understudied, we examined its expression in EAE and in vitro. MMP-12 transcripts increased with EAE, and protein was localized to a subset of macrophages/microglia. The temporal expression of MMP-12 largely corresponded to that of cytokines, and we demonstrate that IL-1 beta and TNTF-alpha promoted MMP-12 expression in cultured macrophages. We Postulate that cytokine - MMP-12 interactions are important in the disease process of EAE. (C) 2008 Elsevier B.V. All rights reserved.
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