Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 197, Issue 2, Pages 114-123Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2008.04.021
Keywords
chemokines; inflammation; neuroimmunology
Categories
Funding
- NIDA NIH HHS [DA13429, DA16544, R01 DA016544, R01 DA014230, R01 DA014230-08, R01 DA006650-17, DA14230, DA06650, P30 DA013429-09, R01 DA016544-04, P30 DA013429, R01 DA006650] Funding Source: Medline
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We previously characterized multiple interactions between chemokine and opioid G protein-coupled receptors (GPCR), and we found both P and delta-opioid receptors cross-desensitize CCR1, CCR2, CCR5, but not CXCR4. Here we report that the K-opioid receptor (KOR) is able to cross-desensitize CXCR4, and this phenomenon is bi-directional. Chemotactic responses by KOR activation are diminished with prior activation of CXCR4. Additionally, calcium mobilization assays show these cross-desensitization processes occur within seconds of receptor activation, and target receptor internalization is not responsible for desensitization between these receptors. These results have implications for several essential processes including neuronal and lymphocyte development, inflammatory responses, and pain/sensitivity. (C) 2008 Elsevier B.V. All rights reserved.
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