Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 196, Issue 1-2, Pages 116-123Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2008.03.014
Keywords
cytokine; microglia; neurospheres; purinergic receptors; IL-1 beta; TNF alpha
Categories
Funding
- NIAID NIH HHS [P50 AI051519, P30 AI051519] Funding Source: Medline
- NINDS NIH HHS [R01 NS052245-01A2, R01 NS052245, R01 NS052245-02, NS052245] Funding Source: Medline
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Spontaneous calcium activity of neural progenitors is largely dependent on a paracrine signaling mechanism involving release of ATP and activation of purinergic receptors. Although it is well documented that, in mature astrocytes, cytokines modulate the expression levels of certain purinergic receptors, nothing is known about their impact during early stages of development. Here we provide evidence that conditioned medium from activated microglia and interleukin-1 beta, but not tumor necrosis factor-alpha, decrease the frequency of calcium oscillations and reduce the rate of in vitro migration of astrocyte progenitors. Such alterations were due to changes in activity of two purinergic P2 receptors, and not to the amount of released ATP. These results indicate that interleukin-1 beta plays an important role during early stages of CNS development, modulating calcium signaling and cell migration. (C) 2008 Elsevier B.V. All rights reserved.
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