Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 200, Issue 1-2, Pages 115-124Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2008.06.005
Keywords
HAM/TSP; HTLV-1; CN4V; CTL; Foxp3; Viral load
Categories
Funding
- Ministry of Health, Labor and Welfare, Japan
- Ministry of Education, Culture, Sports, Science and Technology, Japan
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Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients show high immune responses to HTLV-1. However, it is unclear whether the cytotoxic T lymphocyte (CTL) responses to other chronic viruses also increase. We investigated the responses in the peripheral blood by using HLA-A*0201/peptide pentamers. The frequency of cytomegalovirus (CMV)-specific CTL tended to be higher in HAM/TSP patients than in healthy controls (HCs). The frequency of CMV-specific CTL positively correlated with that of HTLV-1 Tax-specific CTL. The frequency of Foxp3+ cells in CD4+ lymphocytes tended to be higher in HAM/TSP patients than in ACs and HCs. The expression level of Foxp3 was lower in HAM/TSP patients than in HCs and was inversely correlated with the CMV-specific CTL frequency. A percentage of Foxp3+ cells showed a positive correlation with the HTLV-1 proviral load. These results suggest that a decrease in the Foxp3 expression may contribute to the high immune response to CMV and that the Foxp3+ regulatory T cells may play a role in the immune surveillance of HTLV-1. (c) 2008 Elsevier B.V. All rights reserved.
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