Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 196, Issue 1-2, Pages 159-165Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2008.03.001
Keywords
multiple sclerosis; T-cells; T-cell mediated cytotoxicity; microarray; granzymes
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MS is thought to be mediated by CD4(+) T-helper cells. To investigate the importance of CD8(+) cytotoxic T-cells in MS we analyzed peripheral blood T-cells by DNA microarray, and plasma and CSF levels of granzymes from MS patients and controls. Cytotoxic gene expression was decreased in peripheral T-cells from RRMS patients whereas plasma levels of granzymes were unchanged. However, granzyme levels were elevated in the, CSF of RRMS patients at relapse compared with controls and remission. Thus, CD8+ T-cell-mediated cytotoxicity is confined to the CSF/CNS compartment in RRMS patients and may be involved in the immunopathogenesis of clinical relapses. (C) 2008 Elsevier B.V. All rights reserved.
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