Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 205, Issue 1-2, Pages 44-50Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2008.08.017
Keywords
GABAA; Tonic current; Inhibition; T cell
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Funding
- Swedish Research Council-Medicine
- Swedish Research Council-Natural Science
- Crafoord Foundation
- Segerfalks Foundation
- Lund University Diabetes Centre
- Bibi & Nils Jensen's Foundation
- Lundbeck Foundation-Denmark
- Danish Cancer Society
- Danish Multiple Sclerosis Society
- Danish Research Council.
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gamma-aminobutyric acid (GABA) is the main neuroinhibitory transmitter in the brain. Here we show that GABA in the extracellular space may affect the fate of pathogenic T lymphocytes entering the brain. We examined in encephalitogenic T cells if they expressed functional GABA channels that could be activated by the low (nM-1 mu M), physiological concentrations of GABA present around neurons in the brain. The cells expressed the alpha 1, alpha 4, beta 2, beta 3, gamma 1 and delta GABAA channel subunits and formed functional, extrasynaptic-like GABA channels that were activated by 1 mu M GABA. 100 nM and higher GABA concentrations decreased T cell proliferation. The results are consistent with GABA being immunomodulatory. (C) 2008 Elsevier B.V. All rights reserved
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