Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 193, Issue 1-2, Pages 38-51Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2007.09.033
Keywords
neuroimmunology; neurovirology; neuroinflammatory disease; T-cell motility; rabies virus; Canine distemper virus
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Collapsin Response Mediator Protein (CRMP)-2 is involved in T-cell polarization and migration. To address the role of CRMP2 in neuro-inflammation. we analyzed its involvement in lymphocyte recruitment to the central nervous system in mouse infected with neurotropic and non-neurotropic virus strains (RABV, CDV). A sub-population of early-activated CD69+CD3+ T lymphocytes highly expressing CRMP2 (CRMP2hi) peaked in the blood, lymph nodes and brain of mice infected with neurotropic viruses, and correlated with severity of disease. They displayed high migratory properties reduced by CRMP2 blocking antibody. These data point out the potential use of CRMT2 as a peripheral indicator of neuro inflammation. (C) 2007 Elsevier B.V. All rights reserved.
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