Journal
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
Volume 7, Issue 4, Pages 774-787Publisher
SPRINGER
DOI: 10.1007/s11481-012-9404-x
Keywords
Wnt signaling; Neural development; CNS patterning; Axon guidance; Dendrite growth; Synapse formation; Synapse function
Categories
Funding
- NIMH [T32 MH089920]
- Center for Neurobiology and Psychiatry at the University of California, San Francisco
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Members of the Wnt family of secreted signaling proteins influence many aspects of neural development and function. Wnts are required from neural induction and axis formation to axon guidance and synapse development, and even help modulate synapse activity. Wnt proteins activate a variety of downstream signaling pathways and can induce a similar variety of cellular responses, including gene transcription changes and cytoskeletal rearrangements. This review provides an introduction to Wnt signaling pathways and discusses current research on their roles in vertebrate neural development and function.
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