Journal
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
Volume 6, Issue 2, Pages 247-259Publisher
SPRINGER
DOI: 10.1007/s11481-011-9266-7
Keywords
HIV neuropathogenesis; Astrocyte; Signaling pathway
Categories
Funding
- NIH [R01 NS060632, R21 A1077329, PO1 AI082971, F31 NS071999]
- Chicago Developmental Center for AIDS Research (D-CFAR) [P30 AI 082151]
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A greater understanding of the interaction between HIV and host signaling pathways that restrict virus production may lead to new methods to purge virus from latent reservoirs and enhance survival/function of cells targeted by HIV. This review highlights the role of the Wnt/beta-catenin pathway as a host factor that represses HIV replication in multiple targets, especially those relevant to HIV in the central nervous system.
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