Journal
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
Volume 12, Issue 1, Pages 1-8Publisher
ELSEVIER
DOI: 10.1016/j.pdpdt.2014.11.002
Keywords
Photodynamic therapy; Optical fiber; Light emitting fabric; Weaving; Embroidery; Micro-perforation
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Funding
- French National Institute of Health and Medical Research (INSERM)
- ANR Emergence Flexitheralight [ANR-12-EMMA-0018]
- European Commission Competitiveness and Innovation Framework Programme PHOS-ISTOS [621103]
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Photodynamic therapy (PDT) is considered to be a promising method for treating various types of cancer. A homogeneous and reproducible illumination during clinical PDT plays a determinant rote in preventing under- or over-treatment. The development of flexible light sources would considerably improve the homogeneity of light delivery. The integration of optical fiber into flexible structures could offer an interesting alternative. This paper aims to describe different methods proposed to develop Side Emitting Optical Fibers (SEOF), and how these SEOF can be integrated in a flexible structure to improve light illumination of the skin during PDT. Four main techniques can be described: (i) light blanket integrating side-glowing optical fibers, (ii) light emitting panel composed of SEOF obtained by micro-perforations of the cladding, (iii) embroidery-based light emitting fabric, and (iv) woven-based light emitting fabric. Woven-based light emitting fabrics give the best performances: higher fluence rate, best homogeneity of light delivery, good flexibility. (C) 2014 Elsevier B.V. All rights reserved.
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