Journal
JOURNAL OF NEUROIMAGING
Volume 22, Issue 2, Pages 155-159Publisher
WILEY
DOI: 10.1111/j.1552-6569.2011.00588.x
Keywords
Stroke; volume; infarct
Funding
- MEC [TIN2010-21089-C03-01]
- Fondo de Investigaciones Sanitarias (FIS) [PI09/00596]
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BACKGROUND AND PURPOSE Infarct volume is used as a surrogate outcome measure in clinical trials of therapies for acute ischemic stroke. ABC/2 is a fast volumetric method, but its accuracy remains to be determined. We aimed to study the accuracy and reproducibility of ABC/2 in determining acute infarct volume with diffusion-weighted imaging. METHODS We studied 86 consecutive patients with acute ischemic stroke. Three blinded observers determined volume with the ABC/2 method, and the results were compared with those of the manual planimetric method. RESULTS The ABC/2 technique overestimated infarct volume by a median false increase (variable ABC/2 volume minus planimetric volume) of 7.33 cm(3) (1.29, 22.170, representing a 162.56% increase over the value of the gold standard (variable ABC/2 volume over planimetric volume) (121.70, 248.52). In each method, the interrater reliability was excellent: the intraclass correlations were.992 and.985 for the ABC/2 technique and planimetric method, respectively. CONCLUSIONS ABC/2 is volumetric method with clinical value but it consistently overestimates the real infarct volume.
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