Journal
JOURNAL OF NEUROIMAGING
Volume 18, Issue 3, Pages 276-281Publisher
WILEY
DOI: 10.1111/j.1552-6569.2008.00263.x
Keywords
ADC; brain tumor; b value; central nervous system; diffusion-weighted MR
Ask authors/readers for more resources
BACKGROUND Our aim was to prospectively assess whether magnetic resonance (MR) diffusion-weighted (DW) imaging using high b values can predict better than b value of 1,000 s/mm(2) the histopathological grade of cerebral gliomas. METHODS Fifty-four patients with histologically verified brain gliomas (35 high-grade and 19 low-grade gliomas) underwent MR DW imaging. Isotropic DW images and apparent diffusion coefficient (ADC) were obtained with b values of 1,000 and 3,000 s/mm(2). Each tumor was evaluated as being hyperintense, iso-intense or hypointense to normal, contratateral-hemisphere white matter. RESULTS Most of the patients with high- and tow-grade gliomas showed areas of increased signal intensity on their isotropic images, obtained with a b value of 1,000 s/mm(2). However, with a b value of 3,000 s/mm(2) the areas of increased signal intensity were seen in 97.1% of the high-grade gliomas, while 94.7% of the tow-grade gliomas showed no area of increased signal intensity. The mean area under the ROC curve for ADC ratio, obtained with a b value of 3,000 s/mm(2), was significantly higher than that obtained with 1,000 S/mm(2) (.932 vs..856, P = .04). CONCLUSION High b value DW MR might be useful as a complementary tool in preoperative assessment of the histopathotogical grading of cerebral gliomas.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available