Journal
JOURNAL OF NEUROGENETICS
Volume 28, Issue 1-2, Pages 5-29Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/01677063.2014.881358
Keywords
neurodevelopmental; neurodegenerative; induced pluripotent stem cells; modeling
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Funding
- Harvard Stem Cell Institute
- National Institute on Aging [R21AG042776]
- National Institute of Mental Health [R21 MH096233]
- Sackler Scholar Programme in Psychobiology
- NIGMS [T32GM007753]
- NIA [T32AG000222]
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Seven years have passed since the initial report of the generation of induced pluripotent stem cells (iPSCs) from adult human somatic cells, and in the intervening time the field of neuroscience has developed numerous disease models using this technology. Here, we review progress in the field and describe both the advantages and potential pitfalls of modeling neurodegenerative and neurodevelopmental diseases using this technology. We include tables with information on neural differentiation protocols and studies that developed human iPSC lines to model neurological diseases. We also discuss how one can: investigate effects of genetic mutations with iPSCs, examine cell fate-specific phenotypes, best determine the specificity of a phenotype, and bring in vivo relevance to this in vitro technique.
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