Journal
JOURNAL OF NEUROGENETICS
Volume 24, Issue 3, Pages 120-132Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/01677063.2010.489625
Keywords
cysteine-string protein; neurodegeneration; neurotransmitter release; synaptic vesicle
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Funding
- NINDS [R03 NS057215-01, R01 NS052664-01, 1R03MH087827-01]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R03MH087827] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS052664, R03NS057215] Funding Source: NIH RePORTER
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Cysteine-string protein (CSP), a member of the DnaJ/Hsp40 family of cochaperones, is critical for maintaining neurotransmitter release and preventing neurodegeneration. CSP likely forms a chaperone complex on synaptic vesicles together with the 70-kDa heat shock cognate (Hsc70) and the small glutamine-rich tetratricopeptide repeat (TPR)-containing protein (SGT) that may control or protect the assembly and activity of SNARE proteins and various other protein substrates. Here, the author summarizes studies that elucidated CSP's neuroprotective role.
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