Journal
JOURNAL OF NEUROENDOCRINOLOGY
Volume 23, Issue 7, Pages 620-626Publisher
WILEY
DOI: 10.1111/j.1365-2826.2011.02148.x
Keywords
refeeding; hypothalamus; energy balance; NPY; AgRP; arcuate nucleus
Categories
Funding
- Monash University [ECD030]
- ARC
- NHMRC [NHMRC 1011274]
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Obesity impairs arcuate (ARC) neuropeptide Y (NPY)/agouti-releated peptide (AgRP) neuronal function and renders these homeostatic neurones unresponsive to the orexigenic hormone ghrelin. In the present study, we investigated the effect of diet-induced obesity (DIO) on feeding behaviour, ARC neuronal activation and mRNA expression following another orexigenic stimulus, an overnight fast. We show that 9 weeks of high-fat feeding attenuates fasting-induced hyperphagia by suppressing ARC neuronal activation and hypothalamic NPY/AgRP mRNA expression. Thus, the lack of appropriate feeding responses in DIO mice to a fast is caused by failure ARC neurones to recognise and/or respond to orexigenic cues. We propose that fasting-induced hyperphagia is regulated not by homeostatic control of appetite in DIO mice, but rather by changes in the reward circuitry.
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