Journal
JOURNAL OF NEUROCHEMISTRY
Volume 148, Issue 4, Pages 447-461Publisher
WILEY
DOI: 10.1111/jnc.14592
Keywords
CNS; myelination; neuronal activity; neurotransmission; oligodendrocyte; OPC
Categories
Funding
- Australian Research Council [DP18010239]
- Australian National Health & Medical Research Council
- Multiple Sclerosis Research Australia postdoctoral fellowship [APP1111041]
- Australian Postgraduate Scholarship
- Melbourne Neuroscience Institute (University of Melbourne) STRAPA Scholarship
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Myelin, the multilayered membrane surrounding many axons in the nervous system, increases the speed by which electrical signals travel along axons and facilitates neuronal communication between distant regions of the nervous system. However, how neuronal signals influence the myelinating process in the CNS is still largely unclear. Recent studies have significantly advanced this understanding, identifying important roles for neuronal activity in controlling oligodendrocyte development and their capacity of producing myelin in both developing and mature CNS. Here, we review these recent advances, and discuss potential mechanisms underpinning activity-dependent myelination and how remyelination may be stimulated via manipulating axonal activity, raising new questions for future research.
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