Journal
JOURNAL OF NEUROCHEMISTRY
Volume 129, Issue 4, Pages 672-682Publisher
WILEY
DOI: 10.1111/jnc.12667
Keywords
CMR; (glc); glucose transport; isoflurane; lumped constant; magnetic resonance spectroscopic imaging; positron emission tomography
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Funding
- Swiss National Competence Center for Biomedical Imaging (NCCBI)
- Centre d'Imagerie BioMedicale (CIBM) of the UNIL
- UNIGE
- HUG
- CHUV
- EPFL
- Leenaards Foundation
- Jeantet Foundation
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The lumped constant (LC) is a correction factor employed to estimate the glucose metabolic rate (CMRglc) from the metabolic rate of a radioactive glucose analog such as F-18-fluorodeoxyglucose (FDG). By combining FDG positron emission tomography (PET) with magnetic resonance spectroscopic imaging (MRSI) of glucose dynamics, we determined the FDG LC in the rat brain under isoflurane anaesthesia.
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