Journal
JOURNAL OF NEUROCHEMISTRY
Volume 109, Issue 1, Pages 1-14Publisher
WILEY
DOI: 10.1111/j.1471-4159.2009.05881.x
Keywords
LTP; mental disorder; receptor recycling; synapse; synaptic plasticity
Categories
Funding
- CNRS, INSERM, Paris Descartes
- Louis Pasteur Universities [ANR-06-003-Neuro-01, ANR-05-Blan-0326-01]
- European Neuroscience Institutes Network [LSHM-CT-2005-019063]
Ask authors/readers for more resources
Among mental disorders, mental retardation has been shown to be caused by various factors including a large array of genetic mutations. On the basis of remarkable progress, the emerging view is that defects in the regulation of synaptic activity and morphogenesis of dendritic spines are apparently common features associated with mutations in several genes implicated in mental retardation. In this review, we will discuss X-linked MR-related gene products that are potentially involved in the normal structure and function of the synapses, with a particular focus on pre- and/or post-synaptic plasticity mechanisms. Progress in understanding the underlying conditions leading to mental retardation will undoubtedly be gained from a closer collaboration of geneticists, physiologists and cognitive neuroscientists, which should enable the establishment of standardized approaches.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available