Journal
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
Volume 190, Issue 11, Pages 1803-1813Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10426507.2015.1024784
Keywords
Thiophene-fused pyrazole; 1; 3; 4-oxadiazole; antioxidant; anti-inflammatory; antimicrobial; EC50
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Funding
- University Grants Commission, New Delhi
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A series of newer 1,3,4-oxadiazole derivatives 3a-h, 5a-h containing a thiophene fused with pyrazole moiety of pharmacological significance have been synthesized. The compounds were characterized by H-1 NMR, IR, and mass spectral techniques. The compounds were screened for their in vitro antioxidant, anti-inflammatory and antimicrobial activities. Among them, Compounds 3b (EC50-14.98) and 3f (EC50-12.21) showed significant antioxidant activity. Compound 3a (EC50-15.23) showed good anti-inflammatory activity. Compound 3d was found as the most active derivative against bacterial and fungal strains.
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