Journal
JOURNAL OF NEURO-ONCOLOGY
Volume 106, Issue 2, Pages 217-224Publisher
SPRINGER
DOI: 10.1007/s11060-011-0679-1
Keywords
MicroRNA; Glioma; EGFR; PTEN; AKT
Categories
Funding
- China Natural Science Foundation [30872657, 30971136, 81072078]
- Natural Science Foundation of Jiangsu Province [2008475, 2010580]
- Ministry of Health [W2011BX009]
- First Affiliated Hospital of NJMU
- Jiangsu Higher Education Institutions
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Gliomas are the most common type of malignant primary brain tumor. Despite advances in surgery, radiation therapy, and chemotherapy, the prognosis of patients with gliomas has not significantly improved. MicroRNAs (miRNAs), a class of non-coding RNAs, 21-25 nucleotides long, negatively regulate the expression of target genes by interacting with specific sites in mRNAs, and play a critical role in the development of gliomas. The EGFR/PTEN/AKT pathway is a promising target for anti-glioma therapy. Recent studies have showed that regulation of the EGFR/PTEN/AKT pathway by miRNAs plays a major role in glioma progression, indicating a novel way to investigate the tumorigenesis, diagnosis, and therapy of gliomas. Here, we focus on recent findings of miRNAs with respect to the EGFR/PTEN/AKT pathway in gliomas.
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