Journal
JOURNAL OF NEURO-ONCOLOGY
Volume 96, Issue 1, Pages 97-102Publisher
SPRINGER
DOI: 10.1007/s11060-009-0056-5
Keywords
Brain metastases; Anticonvulsant; Prophylaxis; Seizures; Systematic review; Practice guideline
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Do prophylactic anticonvulsants decrease the risk of seizure in patients with metastatic brain tumors compared with no treatment? Target population These recommendations apply to adults with solid brain metastases who have not experienced a seizure due to their metastatic brain disease. Recommendation Level 3 For adults with brain metastases who have not experienced a seizure due to their metastatic brain disease, routine prophylactic use of anticonvulsants is not recommended. Only a single underpowered randomized controlled trial (RCT), which did not detect a difference in seizure occurrence, provides evidence for decision-making purposes.
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