Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 122, Issue 3, Pages 343-348Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-014-1292-1
Keywords
Serotonin; Soluble leptin receptor; Eating disorders; Leptin
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Funding
- Excellence Initiative of the German federal government
- Excellence Initiative of the German state government
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Serotonin (5-HT) and the hormone leptin have been linked to the underlying neurobiology of appetite regulation with evidence coming from animal and cellular research, but direct evidence linking these two pathways in humans is lacking. We examined the effects of reduced brain 5-HT synthesis due to acute tryptophan depletion (ATD) on levels of soluble leptin receptor (sOb-R), the main high-affinity leptin binding protein, in healthy adults using an exploratory approach. Women, but not men, showed reduced sOb-R concentrations after ATD administration. With females showing reduced baseline levels of central 5-HT synthesis compared to males diminished brain 5-HT synthesis affected the leptin axis through the sOb-R in females, thereby potentially influencing their vulnerability to dysfunctional appetite regulation and co-morbid mood symptoms.
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