Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 119, Issue 7, Pages 789-797Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-012-0797-8
Keywords
Alzheimer's disease; Complement; Biomarkers; C3; C4; CR1
Categories
Funding
- Sahlgrenska Academy
- Swedish Research Council [K2010-63P-21562-01-4, K2011-61X-20401-05-6, K2011-62X-21857-01-6, K2011-62X-21710-01-1, K2010-62X-12600-13-3]
- Soderberg Foundation
- Alzheimer's Association
- Gun and Bertil Stohne's Foundation
- Stiftelsen for Gamla Tjanarinnor
- Swedish Alzheimer Foundation
- ALF
- Swedish State
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Alzheimer's disease (AD) is strongly associated with loss of synapses. The complement system has been shown to be involved in synaptic elimination. Several studies point to an association between AD and the complement system. The purpose of this study was to examine the association of cerebrospinal fluid (CSF) levels of complement components 3 and 4 (C3 and C4, respectively), and complement receptor 1 (CR1) with AD in 43 patients with AD plus dementia, 42 patients with mild cognitive impairment (MCI) who progressed to AD during follow-up (MCI-AD), 42 patients with stable MCI and 44 controls. Complement levels were also applied in a multivariate model to determine if they provided any added value to the core AD biomarkers A beta 42, T-tau and P-tau. We found elevated CSF levels of C3 and C4 in AD compared with MCI without progression to AD, and elevated CSF levels of CR1 in MCI-AD and AD when these groups were merged. These results provide support for aberrant complement regulation as a part in the AD process, but the changes are not diagnostically useful.
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