Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 119, Issue 2, Pages 151-154Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-011-0755-x
Keywords
Neuroprotection; Epilepsy; Blood-brain barrier; Synthetic analog; Hippocampus; Pentylenetetrazole
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Funding
- OTKA [K75628]
- Neurosciene Research Group of the Hungarian Academy of Sciences and University of Szeged
- [TAMOP-4.2.1/B-09/1/KONV-2010-0005]
- [-4.2.2/B-10/1-2010-0012]
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The concentration of kynurenic acid (KYNA) in the cerebrospinal fluid, which is in the nanomolar range, is known to decrease in epilepsy. The experimental data suggest that treatment with l-KYN dose dependently increases the concentration of the neuroprotective KYNA in the brain, which itself hardly crosses the blood-brain barrier. However, it is suggested that new synthetic KYNA analogs may readily cross the blood-brain barrier. In this study, we tested the hypothesis that a new KYNA analog administered systemically in a sufficient dose results in a decreased population spike activity recorded from the pyramidal layer of area CA1 of the hippocampus, and also provides protection against pentylenetetrazole-induced epileptiform seizures.
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