4.3 Article

On the origin of the triplet puzzle of homologies in receptor heteromers: toll-like receptor triplets in different types of receptors

Journal

JOURNAL OF NEURAL TRANSMISSION
Volume 119, Issue 5, Pages 517-523

Publisher

SPRINGER WIEN
DOI: 10.1007/s00702-011-0734-2

Keywords

GABAB receptor; Triplet homology; Protein-protein interactions

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Based on our theory, we have discovered main triplets of amino acid residues in the GABAB1 receptor and several other neural receptors, which seem to originate from toll-like receptors and appear also as homologies in receptor heteromers. The obtained results strengthen our hypothesis that these triplets may 'guide-and-clasp' receptor-receptor interactions.

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