Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 118, Issue 10, Pages 1453-1460Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-011-0631-8
Keywords
Deep brain stimulation; Parkinson's disease; Pedunculopontine nucleus; Primate research; Diffusion tensor imaging
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Funding
- UK Medical Research Council
- Norman Collisson Foundation
- Charles Wolfson Charitable Trust
- Oxford Comprehensive Biomedical Research Centre
- MRC [G0701698] Funding Source: UKRI
- Medical Research Council [G0701698] Funding Source: researchfish
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Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here we summarise our non-human primate investigations of relevance to our surgical targeting of the PPN and relate the primate research to initial clinical experience of PPN DBS.
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