Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 119, Issue 6, Pages 701-707Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-011-0747-x
Keywords
Cannabinoid; Amygdala; Subgenual anterior cingulate; Emotion; fMRI
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Funding
- Brain Research Imaging Center at University of Chicago
- National Institutes of Health (NIH) [MH076198, DA024197, DA002812, DA009133]
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Cannabinoids affect positive and negative affective experience and emotional perception, possibly by modulating limbic brain reactivity. In this double-blind crossover, placebo-controlled functional magnetic resonance imaging study in humans, an acute oral dose of Delta(9)-tetrahydrocannabinol (THC) attenuated subgenual anterior cingulate cortex (sgACC) reactivity during the induction of negative affect. This observation extends prior findings implicating a cortico-limbic, emotion-related central mechanism underlying cannabinoid function.
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