4.3 Article

Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect

Journal

JOURNAL OF NEURAL TRANSMISSION
Volume 119, Issue 6, Pages 701-707

Publisher

SPRINGER WIEN
DOI: 10.1007/s00702-011-0747-x

Keywords

Cannabinoid; Amygdala; Subgenual anterior cingulate; Emotion; fMRI

Funding

  1. Brain Research Imaging Center at University of Chicago
  2. National Institutes of Health (NIH) [MH076198, DA024197, DA002812, DA009133]

Ask authors/readers for more resources

Cannabinoids affect positive and negative affective experience and emotional perception, possibly by modulating limbic brain reactivity. In this double-blind crossover, placebo-controlled functional magnetic resonance imaging study in humans, an acute oral dose of Delta(9)-tetrahydrocannabinol (THC) attenuated subgenual anterior cingulate cortex (sgACC) reactivity during the induction of negative affect. This observation extends prior findings implicating a cortico-limbic, emotion-related central mechanism underlying cannabinoid function.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.3
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available