Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 118, Issue 3, Pages 389-396Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-010-0511-7
Keywords
Neurodegeneration; FRDA; NBIA; Drosophila; Iron accumulation
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Funding
- Eric Roland Interdisciplinary Program in Neurodegenerative Diseases
- HFSP
- Abisch-Frenkel Foundation
- Fritz-Thyssen Foundation
- German-Israeli Foundation
- Legacy Found from the Israel Science Foundation
- EU
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The present review focuses on the development and use of Drosophila for modeling neurodegenerative disorders that involve iron accumulation, in particular Friedrich's Ataxia (FRDA) and Neurodegeneration with Iron accumulation (NBIA). Several Drosophila models of such disorders have been introduced successfully in the last few years. Here we review these models and note on the feasibility and advantages of using fly models for understanding the molecular and cellular bases of these devastating diseases.
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