Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 117, Issue 9, Pages 1115-1117Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-010-0442-3
Keywords
Case-control study; MTHFR; Schizophrenia
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Funding
- National Natural Science Foundation of China [30500181]
- Shanghai Natural Science Foundation [10ZR1425700]
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Previous work suggests that the methylenetetrahydrofolate reductase gene (MTHFR) functional polymorphism A1298C may be a risk factor for schizophrenia. In this study, the genetic association between the MTHFR A1298C polymorphism and schizophrenia was investigated in 379 patients with schizophrenia and 380 age- and sex-matched controls subjects. The results showed an association between the 1298C allele and the disorder (OR 1.39, 95% confidence interval 1.08-1.79). This provides further evidence that the MTHFR A1298C polymorphism may play a role in conferring risk for schizophrenia in the Chinese Han population.
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