Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 370, Issue 1679, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rstb.2015.0025
Keywords
SecYEG; Tat; protein translocation; protein secretion
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Funding
- BBSRC [BB/I008675/1]
- SWBio DTP
- Biotechnology and Biological Sciences Research Council [BB/I008675/1] Funding Source: researchfish
- BBSRC [BB/I008675/1] Funding Source: UKRI
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The structure of the first protein-conducting channel was determined more than a decade ago. Today, we are still puzzled by the outstanding-problem of protein translocation the dynamic mechanism underlying the consignment of proteins across and into membranes. This review is an attempt to summarize and understand the energy transducing capabilities of protein-translocating machines, with emphasis on bacterial systems: how polypeptides make headway against the lipid bilayer and how the process is coupled to the free energy associated with ATP hydrolysis and the transmembrane protein motive force. In order to explore how cargo is driven across the membrane, the known structures of the protein-translocation machines are set out against the background of the historic literature, and in the light of experiments conducted in their wake. The paper will focus on the bacterial general secretory (Sec) pathway (SecY-complex), aunts eukaryotic counterpart (Sec61-complex), which ferry proteins across the membrane in an unfolded state, as well as the unrelated Tat system that assembles bespoke channels for the export of folded proteins.
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