Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 370, Issue 1679, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rstb.2015.0027
Keywords
lipopolysaccharide transport; outer membrane; beta-barrel; lipoprotein; envelope biogenesis
Categories
Funding
- Ohio State University
- National Institute of General Medical Sciences of the National Institutes of Health [R01GM100951]
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [R01AI081059, U19AI109764]
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Gram-negative bacteria possess an outer membrane (OM) containing lipopolysaccharide (LPS). Proper assembly of the OM not only prevents certain antibiotics from entering the cell, but also allows others to be pumped out To assemble this barrier, the seven-protein lipopolysaccharide transport (Lpt) system extracts LPS from the outer leaflet of the inner membrane OM), transports it across the periplasm and inserts it selectively into the outer leaflet of the OM. As LPS is important, if not essential, in most Gram-negative bacteria, the LPS biosynthesis and biogenesis pathways are attractive targets in the development of new classes of antibiotics. The accompanying paper (Simpson BW, May JM, Sherman DJ, Kahne D, Ruiz N. 2015 Phil. Trans. R. Soc. B 370, 20150029. (doi:10.1098/rstb.2015.0029)) reviewed the biosynthesis of LPS and its extraction from the IM. This paper will trace its journey across the periplasm and insertion into the OM.
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