Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 370, Issue 1671, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rstb.2014.0138
Keywords
infectious disease; vaccine; immunology; vaccinology; immunization
Categories
Funding
- MRC [MC_UP_A900_1122, MC_EX_MR/K011944/1, MR/K010174/1] Funding Source: UKRI
- Medical Research Council [MR/K010174/1, MC_EX_MR/K011944/1, MC_UP_A900_1122] Funding Source: Medline
- Department of Health [SRF-2009-02-07] Funding Source: Medline
- Medical Research Council [MR/K010174/1, MR/K010174/1B, MC_EX_MR/K011944/1, MC_UP_A900_1122] Funding Source: researchfish
- National Institute for Health Research [SRF-2009-02-07] Funding Source: researchfish
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The reason for holding a meeting to discuss biological challenges to vaccines is simple: not all vaccines work equally well in all settings. This special issue reviews the performance of vaccines in challenging environments, summarizes current thinking on the reasons why vaccines underperform and considers what approaches are necessary to understand the heterogeneity in responses and to improve vaccine immunogenicity and efficacy.
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